Health issues are rarely isolated. They cross borders and travel through human and non-human channels around the globe. Global health governance takes place through both multilateral discussions between nations as well as through a variety of organizations that have been created to address the expected and unexpected consequences of global health issues. This course introduces students to the primary governmental, intergovernmental, private, and civil society actors in global health, offering both a history of how and when these actors came to be, and an account of their shifting interrelationships in the face of evolving global health crises. Students learn about the post-World War II development of the World Health Organization, the World Bank, and the United Nations and its agencies on one hand, and about the parallel development of civil society organizations like OXFAM, CARE, and Catholic Relief Services on the other. The course then explores the development of governmental organizations like the CDC and USAID in the United States and an DFID in the United Kingdom, and, in the 1990s and 2000s, the addition of large private actors like the Gates Foundation and new models of governance like the Global Fund and UNAIDS. The course examines the tensions, struggles, challenges, and successes of these international organizations and their relationships and processes, through case studies of how these organizations have interacted, individually and collectively, with various countries and communities in which global health crises have emerged. In this way, the course uses global health governance as a lens through which to view many of the driving issues in global health: HIV/AIDS, malaria, tuberculosis, and a rising tide of new infectious diseases; the alarming global spread of diabetes, obesity, and cancer; the persistence of malnutrition and the deaths of children under five; violence, war, and mental health; and the continuing challenges of reproductive and maternal health. The solutions to all of these pressing global health issues, and many others as well, will be a product of global health governance.